Origin and evolution of nuclear localization signals
نویسندگان
چکیده
منابع مشابه
Finding nuclear localization signals.
A variety of nuclear localization signals (NLSs) are experimentally known although only one motif was available for database searches through PROSITE. We initially collected a set of 91 experimentally verified NLSs from the literature. Through iterated 'in silico mutagenesis' we then extended the set to 214 potential NLSs. This final set matched in 43% of all known nuclear proteins and in no kn...
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The transport of nuclear proteins is a very important step for the maintenance of life. Most proteins that function in the nucleus are moved through the nuclear envelope that is penetrated by the nuclear pores. The nuclear pore is formed by a large, complex structure known as the nuclear pore complex (NPC). The NPC is a major gateway for mediating ions, small molecules, proteins, RNAs, and ribo...
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NLSdb is a database of nuclear localization signals (NLSs) and of nuclear proteins. NLSs are short stretches of residues mediating transport of nuclear proteins into the nucleus. The database contains 114 experimentally determined NLSs that were obtained through an extensive literature search. Using 'in silico mutagenesis' this set was extended to 308 experimental and potential NLSs. This final...
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Eukaryotic ribosomal proteins, unlike their bacterial homologues, possess nuclear localization signals (NLSs) to enter the cell nucleus during ribosome assembly. Here we provide a comprehensive comparison of bacterial and eukaryotic ribosomes to show that NLSs appear in conserved ribosomal proteins via remodelling of their RNA-binding domains. This finding enabled us to identify previously unkn...
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1-Introduction Travertines are limestones that form where hot groundwaters rich in calcium and bicarbonate emerge at springs. Travertines cover a large area southwest of Azarshahr (East Azarbaijan province), in some parts of which active springs are currently settling travertine. One of the main questions about travertine springs is their origin, as well as the secondary processes that have ch...
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ژورنال
عنوان ژورنال: Biopolymers and Cell
سال: 2019
ISSN: 0233-7657,1993-6842
DOI: 10.7124/bc.0009c5